Journal of Medical Screening > Volume 16, Number 2 > Pp. 102-103

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Short Communication

Adjustment of serum markers in first trimester screening

Geralyn Lambert-MesserlianPhD, Associate Professor  , Department of Pathology and Laboratory Medicine, Women and Infants Hospital and the Alpert Medical School of Brown University, Providence, RI 02903

Glenn E PalomakiBS, Statistician , Department of Pathology and Laboratory Medicine, Women and Infants Hospital and the Alpert Medical School of Brown University, Providence, RI 02903

Jacob A CanickPhD, Professor , Department of Pathology and Laboratory Medicine, Women and Infants Hospital and the Alpert Medical School of Brown University, Providence, RI 02903

Correspondence to: Geralyn Lambert-Messerlian PhD, Division of Medical Screening and Special Testing, Women and Infants Hospital, 70 Elm Street, Providence, RI 02903 USA; gmesserl{at}wihri.org

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First trimester combined screening can be performed using maternal serum pregnancy-associated plasma protein A, total human chorionic gonadotropin (hCG) and ultrasound measurement of nuchal translucency at 11–13 weeks of pregnancy. Our objective was to explore the effects of covariates on total hCG in the first trimester. First trimester total hCG levels were significantly increased in twins (median = 1.87 MoM), mildly increased in pregnancies achieved by in vitro fertilization (1.04 MoM) and decreased in smokers (0.80 MoM).

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