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Journal of Medical Screening

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J Med Screen 2008;15:204-206
doi:10.1258/jms.2008.008049
© 2008 Medical Screening Society

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First trimester Down's syndrome screening marker values and cigarette smoking: new data and a meta-analysis on free β human chorionic gonadotophin, pregnancy-associated plasma protein-A and nuchal translucency

Jonathan P Bestwick, Statistician  , Wolfson Institute of Preventive Medicine, Barts and the London Queen Marys School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ

Wayne J Huttly, Antenatal screening manager , Wolfson Institute of Preventive Medicine, Barts and the London Queen Marys School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ

Nicholas J Wald, Professor , Wolfson Institute of Preventive Medicine, Barts and the London Queen Marys School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ


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  		Figure 1 Published studies of free β-human chorionic gonadotrophin (free β-hCG), pregnancy-associated plasma protein-A (PAPP-A) and nuchal translucency (NT) measured at 10–13 weeks gestation in pregnancies of women who smoke compared to women who do not smoke, showing the median multiple of the median (MoM) value and number of pregnancies in each study, together with a pooled estimate of the median with 95% CI and the median in non-smokers (solid line, median set to 1.0 MoM)

 

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