Journal of Medical Screening >
Volume 8, Number 3 >
Pp. 137-144
Original Papers |
A randomised, controlled trial in progress in 14 United Kingdom and six Italian centres is evaluating screening for colorectal cancer using a single flexible sigmoidoscopy (FS) at around the age of 60 with removal during FS of all small adenomas, and colonoscopy for "high risk" polyps. The regimen aims to ensure that 95% of people (with either no polyps or only low risk polyps) complete the entire screening process in a single visit. This paper describes the rationale and design of the trial. Participants were patients aged between 55 and 64 on the lists of designated general practitioners (GPs) who were not excluded by their GP. A two stage recruitment procedure was employed to raise compliance rates in the intervention group. Potentially eligible persons were sent an "interest in screening" questionnaire; those who responded positively were randomised to the intervention or control groups. The trial is sufficiently large to estimate within narrow confidence intervals the magnitude of benefit and the duration of effect and optimum age for a single screen. It also examines the feasibility and acceptability of the screening regimen, and will identify training and quality assurance issues. Recruitment and screening are now complete and all baseline data have been collected. The first analysis of the effect on colorectal cancer incidence and mortality rates and suitability for a national screening programme can be expected in 2004.8
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
|
|
 |
|
  I. Lansdorp-Vogelaar, M. van Ballegooijen, A. G. Zauber, J. D. F. Habbema, and E. J. Kuipers Effect of Rising Chemotherapy Costs on the Cost Savings of Colorectal Cancer Screening J Natl Cancer Inst, October 21, 2009; 101(20): 1412 - 1422. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Miles, W. S Atkin, I. Kralj-Hans, and J. Wardle The psychological impact of being offered surveillance colonoscopy following attendance at colorectal screening using flexible sigmoidoscopy J Med Screen, September 1, 2009; 16(3): 124 - 130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Hoff, T. Grotmol, E. Skovlund, M. Bretthauer, and for the Norwegian Colorectal Cancer Prevention Stu Risk of colorectal cancer seven years after flexible sigmoidoscopy screening: randomised controlled trial BMJ, May 29, 2009; 338(may29_2): b1846 - b1846. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D M Parkin, P Tappenden, A H Olsen, J Patnick, and P Sasieni Predicting the impact of the screening programme for colorectal cancer in the UK J Med Screen, December 1, 2008; 15(4): 163 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
U. Menon, A. Gentry-Maharaj, A. Ryan, A. Sharma, M. Burnell, R. Hallett, S. Lewis, A. Lopez, K. Godfrey, D. Oram, et al. Recruitment to multicentre trials--lessons from UKCTOCS: descriptive study BMJ, November 13, 2008; 337(nov13_1): a2079 - a2079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. A Robb, E. Power, W. Atkin, and J. Wardle Ethnic differences in participation in flexible sigmoidoscopy screening in the UK J Med Screen, September 1, 2008; 15(3): 130 - 136. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. N. Mitrou, M. A. Watson, A. S. Loktionov, C. Cardwell, M. J. Gunter, W. S. Atkin, C. P. Macklin, T. Cecil, D.T. Bishop, J. Primrose, et al. Role of NQO1C609T and EPHX1 gene polymorphisms in the association of smoking and alcohol with sporadic distal colorectal adenomas: results from the UKFSS Study Carcinogenesis, April 1, 2007; 28(4): 875 - 882. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. Schoenfeld, B. Cash, A. Flood, R. Dobhan, J. Eastone, W. Coyle, J. W. Kikendall, H. M. Kim, D. G. Weiss, T. Emory, et al. Colonoscopic Screening of Average-Risk Women for Colorectal Neoplasia N. Engl. J. Med., May 19, 2005; 352(20): 2061 - 2068. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. E. Simon, A. Steptoe, and J. Wardle Socioeconomic Status Differences in Coping With a Stressful Medical Procedure Psychosom Med, March 1, 2005; 67(2): 270 - 276. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. S. Fearnhead, J. L. Wilding, B. Winney, S. Tonks, S. Bartlett, D. C. Bicknell, I. P. M. Tomlinson, N. J. McC. Mortensen, and W. F. Bodmer Multiple rare variants in different genes account for multifactorial inherited susceptibility to colorectal adenomas PNAS, November 9, 2004; 101(45): 15992 - 15997. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Miles, J. Wardle, K. McCaffery, S. Williamson, and W. Atkin The Effects of Colorectal Cancer Screening on Health Attitudes and Practices Cancer Epidemiol. Biomarkers Prev., July 1, 2003; 12(7): 651 - 655. [Full Text] [PDF]
|
|
|
|
|
|
N. Segnan, C. Senore, B. Andreoni, H. Aste, L. Bonelli, C. Crosta, R. Ferraris, S. Gasperoni, A. Penna, M. Risio, et al. Baseline Findings of the Italian Multicenter Randomized Controlled Trial of "Once-Only Sigmoidoscopy"--SCORE J Natl Cancer Inst, December 4, 2002; 94(23): 1763 - 1772. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E D A Westcott and A C J Windsor Can we improve the outcome of colorectal cancer by early diagnosis? Postgrad. Med. J., May 1, 2002; 78(919): 255 - 256. [Full Text] [PDF]
|
|
|
|
|
|
A. H. Baker and J. Wardle Increasing Fruit and Vegetable Intake Among Adults Attending Colorectal Cancer Screening: The Efficacy of a Brief Tailored Intervention Cancer Epidemiol. Biomarkers Prev., February 1, 2002; 11(2): 203 - 206. [Abstract] [Full Text] [PDF]
|
|
